Christophe wrote a Spotlight in the Journal of Cell Biology highlighting a nice recent paper from the group of Pei-Lin Cheng in Taiwan. In this article, Lee et al. showed how degradation of the chloride transporter NKCC1 by proteasomes anchored at the AIS have a key role in lowering the intracellular chloride concentration, leading to the perinatal reversal of GABA effect from excitatory to inhibitory.
![](https://i0.wp.com/www.neurocytolab.org/wp-content/uploads/2020/01/jcb_201912006_fig1.png?fit=525%2C236)