Preprints
Surpassing Challenges in Structured-Illumination Microscopy with FlexSIM.
Soubies E, Nogueron A, Pelletier F, Mangeat T, Leterrier C, Unser M, Sage D.
bioRxiv, 2023 Dec 21.
doi : 10.1101/2023.12.20.572677
The actin-spectrin submembrane scaffold restricts endocytosis along proximal axons.
Wernert F, Moparthi SB, Lainé J, Moulay G, Boroni-Rueda F, Pelletier F, Jullien N, Benkhelifa-Ziyat S, Papandreou MJ, Leterrier C*, Vassilopoulos S*.
bioRxiv, 2023 Dec 19.
doi : 10.1101/2023.12.19.572337
pHusion: A robust and versatile toolset for automated detection and analysis of exocytosis.
O’Shaughnessy EC, Lam M, Ryken SE, Wiesner T, Lukasik K, Zuchero JB, Leterrier C, Adalsteinsson D, Gupton SL.
bioRxiv, 2023 Jul 25.
doi: 10.1101/2023.07.25.550499
Actomyosin-mediated nanostructural remodeling of the presynaptic vesicle pool by cannabinoids induces long-term depression.
McFadden MH, Xu H, Cui Y, Piskorowski RA, Leterrier C, Zala D, Venance L, Chevaleyre V, Lenkei Z.
bioRxiv, 2018 Oct 16.
doi: 10.1101/444950
Publications
2023
Decoding life’s inner workings: advances in quantitative bioimaging.
Henriques R, Leterrier C, Weigel A.
Open Biology, 2023;13(11):230329.
doi: 10.1098/rsob.230329
High-fidelity 3D live-cell nanoscopy through data-driven enhanced super-resolution radial fluctuation.
Laine RF, Heil HS, Coelho S, Nixon-Abell J, Jimenez A, Wiesner T, Martínez D, Galgani T, Régnier L, Stubb A, Follain G, Webster S, Goyette J, Dauphin A, Salles A, Culley S, Jacquemet G, Hajj B*, Leterrier C*, Henriques R*.
Nature Methods, 2023; 1–8.
doi: 10.1038/s41592-023-02057-w
Microtubules under mechanical pressure can breach dense actin networks.
Gélin M, Schaeffer A, Gaillard J, Guérin C, Vianay B, Orhant-Prioux M, Braun M, Leterrier C, Blanchoin L, Théry M.
The Journal of Cell Science, 2023.
doi: 10.1242/jcs.261667
Assessing crosstalk in simultaneous multicolor single-molecule localization microscopy.
Friedl K, Mau A, Boroni-Rueda F, Caorsi V, Bourg N, Lévêque-Fort S, Leterrier C.
Cell Reports Methods, 2023;100571.
doi: 10.1016/j.crmeth.2023.100571
Presynapses contain distinct actin nanostructures.
Bingham D, Jakobs CE, Wernert F, Boroni-Rueda F, Jullien N, Schentarra EM, Friedl K, Da Costa Moura J, van Bommel DM, Caillol G, Ogawa Y, Papandréou MJ, Leterrier C.
The Journal of Cell Biology, 2023;222(10):e202208110.
doi: 10.1083/jcb.202208110
Open-3DSIM: an open-source three-dimensional structured illumination microscopy reconstruction platform.
Cao R, Li Y, Chen X, Ge X, Li M, Guan M, Hou Y, Fu Y, Xu X, Leterrier C, Jiang S, Gao B, Xi P.
Nature Methods, 2023 Aug;20(8):1183-1186.
doi: 10.1038/s41592-023-01958-0
Super-resolved total internal reflection fluorescence microscopy using random illuminations.
Affannoukoué K, Labouesse S, Maire G, Gallais L, Savatier J, Allain M, Rasedujjaman M, Legoff L, Idier J, Poincloux R, Pelletier F, Leterrier C, Mangeat T, Sentenac A.
Optica, 2023;10(8):1009.
doi: 10.1364/optica.487003
Microtubules self-repair in living cells.
Gazzola M, Schaeffer A, Butler-Hallissey C, Friedl K, Vianay B, Gaillard J, Leterrier C, Blanchoin L, Théry M.
Current Biology, 2023;33(1):122-133.e4.
doi: 10.1016/j.cub.2022.11.060
2022
ShareLoc – an open platform for sharing localization microscopy data.
Ouyang W, Bai J, Singh MK, Leterrier C, Barthelemy P, Barnett SFH, Klein T, Sauer M, Kanchanawong P, Bourg N, Cohen MM, Lelandais B, Zimmer C.
Nature Methods, 2022;19(11):1331–3.
doi: 10.1038/s41592-022-01659-0
Mechanical role of the submembrane spectrin scaffold in red blood cells and neurons.
Leterrier C, Pullarkat PA.
The Journal of Cell Science, 2022 Aug 15;135(16).
doi: 10.1242/jcs.259356
Mapping molecular complexes with Super-Resolution Microscopy and Single-Particle Analysis.
Mendes A, Heil HS, Coelho S, Leterrier C, Henriques R.
Open Biology, 2022 Jul;12(7):220079.
doi: 10.1098/rsob.220079
Rings and braids: Correlative microscopy reveals the structure of axonal actin.
Vassilopoulos S, Leterrier C.
Médecine/Sciences, 2022 Feb;38(2):130-133.
doi: 10.1051/medsci/2021254
2021
Convergence of adenosine and GABA signaling for synapse stabilization during development.
Gomez-Castro F, Zappettini S, Pressey JC, Silva CG, Russeau M, Gervasi N, Figueiredo M, Montmasson C, Renner M, Canas PM, Gonçalves FQ, Alçada-Morais S, Szabó E, Rodrigues RJ, Agostinho P, Tomé AR, Caillol G, Thoumine O, Nicol X, Leterrier C, Lujan R, Tyagarajan SK, Cunha RA, Esclapez M, Bernard C, Lévi S.
Science, 2021 Nov 5;374(6568):eabk2055.
doi: 10.1126/science.abk2055
Clathrin packets move in slow axonal transport and deliver functional payloads to synapses.
Ganguly A, Sharma R, Boyer NP, Wernert F, Phan S, Boassa D, Parra L, Das U, Caillol G, Han X, Yates JR 3rd, Ellisman MH, Leterrier C, Roy S .
Neuron, 2021 Sep 15;109(18):2884-2901.e7.
doi: 10.1016/j.neuron.2021.08.016
Putting the axonal periodic scaffold in order.
Leterrier C.
Current Opinion in Neurobiology, 2021 Aug;69:33-40.
doi: 10.1016/j.conb.2020.12.015
Self-repair protects microtubules from destruction by molecular motors.
Triclin S, Inoue D, Gaillard J, Min Htet Z, De Santis M, Portran D, Derivery E, Aumeier C, Schaedel L, John K, Leterrier C, Reck-Peterson S, Blanchoin L, Thery M.
Nature Materials, 2021 Jun;20(6):883-891.
doi: 10.1038/s41563-020-00905-0
Fast widefield scan provides tunable and uniform illumination optimizing super-resolution microscopy on large fields.
Mau A, Friedl K, Leterrier C, Bourg N, Lévêque-Fort S.
Nature Communications, 2021 May 24;12(1):3077.
doi: 10.1038/s41467-021-23405-4
Democratising deep learning for microscopy with ZeroCostDL4Mic.
von Chamier L, Laine RF, Jukkala J, Spahn C, Krentzel D, Nehme E, Lerche M, Hernández-Pérez S, Mattila PK, Karinou E, Holden S, Solak AC, Krull A, Buchholz TO, Jones ML, Royer LA, Leterrier C, Shechtman Y, Jug F, Heilemann M, Jacquemet G, Henriques R.
Nature Communications, 2021 Apr 15;12(1):2276.
doi: 10.1038/s41467-021-22518-0
Stress fibres are embedded in a contractile cortical network.
Vignaud T, Copos C, Leterrier C, Toro-Nahuelpan M, Tseng Q, Mahamid J, Blanchoin L, Mogilner A, Théry M, Kurzawa L.
Nature Materials, 2021 Mar;20(3):410-420.
doi: 10.1038/s41563-020-00825-z
A pictorial history of the neuronal cytoskeleton.
Leterrier C.
The Journal of Neuroscience, 2021 Jan 6;41(1):11–27.
doi: 10.1523/jneurosci.2872-20.2020
• Check the cover!
2020
vLUME: 3D virtual reality for single-molecule localization microscopy.
Spark A, Kitching A, Esteban-Ferrer D, Handa A, Carr AR, Needham LM, Ponjavic A, Santos AM, McColl J, Leterrier C, Davis SJ, Henriques R, Lee SF.
Nature Methods, 2020 Nov;17(11):1097-1099.
doi: 10.1038/s41592-020-0962-1
Alternative splicing of clathrin heavy chain contributes to the switch from coated pits to plaques.
Moulay G, Lainé J, Lemaître M, Nakamori M, Nishino I, Caillol G, Mamchaoui K, Julien L, Dingli F, Loew D, Bitoun M, Leterrier C, Furling D, Vassilopoulos S.
The Journal of Cell Biology, 2020 Sep 7;219(9).
doi : 10.1083/jcb.201912061
The cell biologist’s guide to super-resolution microscopy.
Jacquemet G*, Carisey AF*, Hamidi H, Henriques R*, Leterrier C*.
The Journal of Cell Science, 2020 133(11), jcs240713.
doi: 10.1242/jcs.240713
About samples, giving examples: Optimized Single Molecule Localization Microscopy.
Jimenez A, Friedl K, Leterrier C.
Methods, 2020 Mar 1;174:100-114.
doi: 10.1016/j.ymeth.2019.05.008
GABA in, garbage out: AIS-located proteasomes regulate the developmental GABA switch.
Leterrier C.
The Journal of Cell Biology, 2020 Feb 3;219(2).
doi: 10.1083/jcb.201912006
Mapping axon initial segment structure and function by multiplexed proximity biotinylation.
Hamdan H, Lim BC, Torii T, Joshi A, Konning M, Smith C, Palmer DJ, Ng P, Leterrier C, Oses-Prieto JA, Burlingame AL, Rasband MN.
Nature Communications, 2020 Jan 3;11(1):100.
doi: 10.1038/s41467-019-13658-5
2019
Ultrastructure of the axonal periodic scaffold reveals a braid-like organization of actin rings.
Vassilopoulos S*, Gibaud S, Jimenez A, Caillol G, Leterrier C*.
Nature Communications, 2019 Dec 20;10(1):5803.
doi: 10.1038/s41467-019-13835-6
A dual role for βII-spectrin in axons.
Leterrier C.
Proceedings of the National Academy of Sciences, 2019 Jul 30;116(31):15324-15326.
doi: 10.1073/pnas.1909789116
Combining 3D single molecule localization strategies for reproducible bioimaging.
Cabriel C, Bourg N, Jouchet P, Dupuis G, Leterrier C, Baron A, Badet-Denisot M-A, Vauzeilles B, Fort E, Lévêque-Fort S.
Nature Communications, 2019 Apr 30;10(1):1642.
doi: 10.1038/s41467-019-09901-81
Automating multimodal microscopy with NanoJ-Fluidics.
Almada P, Pereira P, Culley S, Caillol G, Boroni-Rueda F, Dix CL, Charras G, Baum B, Laine RF*, Leterrier C*, Henriques R*.
Nature Communications, 2019 Mar 15;10(1):1223.
doi: 10.1101/320416
NanoJ: a high-performance open-source super-resolution microscopy toolbox.
Laine RF, Tosheva KL, Gustafsson N, Gray RDM, Almada P, Albrecht D, Risa GT, Hurtig F, Lindås A-C, Baum B, Mercer J, Leterrier C, Pereira PM, Culley S, Henriques R.
Journal of Physics D: Applied Physics, 2019 Jan 29.
doi: 10.1088/1361-6463
Processive flow by biased polymerization mediates the slow axonal transport of actin.
Chakrabarty N, Dubey P, Tang Y, Ganguly A, Ladt K, Leterrier C*, Jung P*, Roy S*.
The Journal of Cell Biology, 2019 Jan 7;218(1):112–24.
doi: 10.1083/jcb.201711022
2018
The functional architecture of axonal actin.
Papandréou M-J, Leterrier C.
Molecular and Cellular Neuroscience, 2018 Sep;91:151-159.
doi: 10.1016/j.mcn.2018.05.003
• Check the cover!
The axon initial segment: an updated viewpoint.
Leterrier C.
The Journal of Neuroscience, 2018 Feb 28;38(9):2135–2145.
doi: 10.1523/jneurosci.1922-17.2018
• Check the cover!
Quantitative mapping and minimization of super-resolution optical imaging artifacts.
Culley S, Albrecht D, Jacobs C, Matos Pereira P, Leterrier C*, Mercer J*, Henriques R*
Nature Methods, 2018 Apr;15(4):263-266.
doi: 10.1038/nmeth.4605
Localized Myosin II Activity Regulates Assembly and Plasticity of the Axon Initial Segment.
Berger SL, Leo-Macias A, Yuen S, Khatri L, Pfennig S, Zhang Y, Agullo-Pascual E, Caillol G, Zhu M-S, Rothenberg E, Melendez-Vasquez CV, Delmar M, Leterrier C, Salzer J.L.
Neuron, 2018 Feb 7;97(3):555-570.e6.
doi: 10.1016/j.neuron.2017.12.039
2017
The nano-architecture of the axonal cytoskeleton.
Leterrier C*, Dubey P, Roy S*.
Nature Reviews Neuroscience, 2017 Dec;18(12):713-726.
doi: 10.1038/nrn.2017.129
αII spectrin forms a periodic cytoskeleton at the axon initial segment and is required for nervous system function.
Huang CY, Zhang C, Ho TS, Oses-Prieto J, Burlingame AL, Lalonde J, Noebels JL, Leterrier C, Rasband MN.
The Journal of Neuroscience, 2017 Nov 22;37(47):11311-11322.
doi: 10.1523/jneurosci.2112-17.2017
• Check the cover!
An αII spectrin based cytoskeleton protects large diameter myelinated axons from degeneration.
Huang CY, Zhang C, Zollinger DR, Leterrier C, Rasband MN.
The Journal of Neuroscience, 2017 Nov 22;37(47):11323-11334.
doi: 10.1523/jneurosci.2113-17.2017
Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin.
Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, Gitler D, Caillol G, Leterrier C, Yates JR 3rd, Roy S.
The Journal of Cell Biology, 2017 Jul 3;216(7):2059-2074
doi: 10.1083/jcb.201604028
Ankyrin G membrane partners drive the establishment and maintenance of the axon initial segment
Leterrier C, Clerc N, Rueda-Boroni F, Montersino A, Dargent B, Castets F.
Frontiers in Cellular Neuroscience, 2017 11:6
doi: 10.3389/fncel.2017.00006
Developmental changes in expression of βVI-spectrin splice variants at axon initial segments and nodes of Ranvier.
Yoshimura T, Stevens S, Leterrier C, Stankewich M, Rasband M.N.
Frontiers in Cellular Neuroscience, 2017 10:304.
doi: 10.3389/fncel.2016.00304
2016
The axon initial segment, 50 years later: a nexus for neuronal organization and function.
Leterrier C.
Current Topics in Membranes, 2016;77:185-233.
doi: 10.1016/bs.ctm.2015.10.005
2015
Nanoscale architecture of the axon initial segment reveals an organized and robust scaffold.
Leterrier C*, Potier J, Caillol G, Rueda-Boroni F, Debarnot C, Dargent B.
Cell Reports, 2015 Dec 29;13(12):2781-93.
doi: 10.1016/j.celrep.2015.11.051
A dynamic formin-dependent deep F-actin network in axons.
Ganguly A, Tang Y, Wang L, Ladt K, Loi J, Dargent B, Leterrier C, Roy S.
The Journal of Cell Biology, 2015 Aug 3;210(3):401-17.
doi: 10.1083/jcb.201506110
• Check the cover!
Previous publications of the NeuroCyto team members
2019
Gangliosides interact with synaptotagmin to form the high-affinity receptor complex for botulinum neurotoxin B.
Flores A, Ramirez-Franco J, Desplantes R, Debreux K, Ferracci G, Wernert F, Blanchard MP, Maulet Y, Youssouf F, Sangiardi M, Iborra C, Popoff MR, Seagar M, Fantini J, Lévêque C, El Far O.
Proceedings of the National Academy of Sciences, 2019 Sep 3;116(36):18098-18108.
doi: 10.1073/pnas.1908051116
2015
CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.
Papandréou M-J, Vacher H, Fache M-P, Klingler E, Rueda-Boroni F, Ferracci G, Debarnot C, Pipéroglou C, Garcia Del Caño G, Goutebroze L, Dargent B.
Journal of Neurochemistry, 2015 Aug;134(3):527-37.
doi: 10.1111/jnc.13158
2014
CK2 accumulation at the axon initial segment depends on sodium channel Nav1.
Hien YE, Montersino A, Castets F, Leterrier C, Filhol O, Vacher H, Dargent B.
FEBS Letters, 2014 Sep 17;588(18):3403-8.
doi: 10.1016/j.febslet.2014.07.032
No Pasaran! Role of the axon initial segment in the regulation of protein transport and the maintenance of axonal identity.
Leterrier C*, Dargent B.
Seminars in Cell & Developmental Biology, 2014 Mar;27:44-51.
doi: 10.1016/j.semcdb.2013.11.001
2013
Activation-dependent plasticity of polarized GPCR distribution on the neuronal surface.
Simon AC, Loverdo C, Gaffuri A-L, Urbanski M, Ladarre D, Carrel D, Rivals I, Leterrier C, Benichou O, Dournaud P, Szabo B, Voituriez R, Lenkei Z.
Journal of Molecular Cell Biology, 2013 Aug;5(4):250-65.
doi: 10.1093/jmcb/mjt014
2012
Motor endplate disease affects neuromuscular junction maturation.
Caillol G, Vacher H, Musarella M, Bellouze S, Dargent B, Autillo-Touati A.
European Journal of Neuroscience, 2012 Aug;36(4):2400-8.
doi: 10.1111/j.1460-9568.2012.08164.x
2011
EB3 and EB1 link microtubules to ankyrin G in the axon initial segment.
Leterrier C, Vacher H, Fache M-P, Angles d’Ortoli S, Castets F, Autillo-Touati A, Dargent B.
Proceedings of the National Academy of Sciences, 2011 May 24;108(21):8826-31.
doi: 10.1073/pnas.1018671108
Determinants of voltage-gated sodium channel clustering in neurons.
Leterrier C, Brachet A, Dargent B, Vacher H.
Seminars in Cell & Developmental Biology, 2011 Apr;22(2):171-7.
doi: 10.1016/j.semcdb.2010.09.014
Axonal targeting of the 5-HT1B serotonin receptor relies on structure-specific constitutive activation.
Carrel D, Simon A, Emerit MB, Rivals I, Leterrier C, Biard M, Hamon M., Darmon M, Lenkei Z.
Traffic, 2011 Nov;12(11):1501-20.
doi: 10.1111/j.1600-0854.2011.01260.x
2010
Ankyrin G restricts ion channel diffusion at the axonal initial segment before the establishment of the diffusion barrier.
Brachet A, Leterrier C, Irondelle M, Fache M-P, Racine V, Sibarita J-B, Choquet D, Dargent B.
The Journal of Cell Biology, 2010 Oct 18;191(2):383-95.
doi: 10.1083/jcb.201003042
Voltage-gated sodium channel organization in neurons: Protein interactions and trafficking pathways.
Leterrier C,Brachet A, Fache M-P, Dargent B.
Neuroscience Letters, 2010 Dec 10;486(2):92-100.
doi: 10.1016/j.neulet.2010.08.079
Clathrin-dependent APP endocytosis and Abeta secretion are highly sensitive to the level of plasma membrane cholesterol.
Cossec J-C, Simon A, Marquer C, Moldrich RX, Leterrier C, Rossier J, Duyckaerts C, Lenkei Z, Potier M-C.
Biochimica et Biophysica Acta (BBA), 2010 Aug;1801(8):846-52.
doi: 10.1016/j.bbalip.2010.05.010
Mapping of domains on HIV envelope protein mediating association with calnexin and protein-disulfide isomerase.
Papandréou M-J, Barbouche R, Guieu R, Rivera S, Fantini J, Khrestchatisky M, Jones IM, Fenouillet E.
The Journal of Biological Chemistry, 2010 Apr 30;285(18):13788-96.
doi: 10.1074/jbc.M109.066670
2009
The somatostatin 2A receptor is enriched in migrating neurons during rat and human brain deve-lopment and stimulates migration and axonal outgrowth.
Le Verche V, Kaindl AM, Verney C, Csaba Z, Peineau S, Olivier P, Adle-Biassette H, Leterrier C, Vitalis T, Renaud J, Dargent B, Gressens P, Dournaud P.
PLoS One, 2009;4(5):e5509.
doi: 10.1371/journal.pone.0005509
2008
Casein kinase 2 contributes to the organization of sodium channel in axonal membranes by regulating interactions with ankyrin G.
Bréchet A, Fache M-P, Brachet A, Ferracci G, Baude A, Irondelle M, Perreira S, Leterrier C, Dargent B.
The Journal of Cell Biology, 2008 Dec 15;183(6):1101-14.
doi: 10.1083/jcb.200805169
The type-1 cannabinoid receptor, highly expressed in embryonic cortical neurons axons, negatively regulates neurite growth in vitro.
Vitalis T, Lainé J, Simon A, Roland A, Leterrier C, Cases O, Lenkei Z.
European Journal of Neuroscience, 2008 Nov;28(9):1705-18.
doi: 10.1111/j.1460-9568.2008.06484.x
2006
Constitutive activation drives compartment-selective endocytosis and axonal targeting of type 1 cannabinoid receptors.
Leterrier C, Lainé J, Darmon M, Boudin H, Rossier J, Lenkei Z.
The Journal of Neuroscience, 2006 March 22; 26(12):3141-3153
doi: 10.1523/JNEUROSCI.5437-05.2006
Expression of Nav1.6 sodium channels by Schwann cells at neuromuscular junctions: role in the motor endplate disease phenotype.
Musarella M, Alcaraz G, Caillol G, Boudier J-L, Couraud F, Autillo-Touati A.
Glia. 2006 Jan 1;53(1):13-23.
doi: 10.1002/glia.20252
2004
Constitutive endocytic cycle of the CB1 cannabinoid receptor.
Leterrier C, Bonnard D, Carrel D, Rossier J, Lenkei Z.
The Journal of Biological Chemistry, 2004 Aug 20;279(34):36013-21.
doi: 10.1074/jbc.M403990200