New article out: Mapping the axon initial segment components by mass spectrometry

First work of 2020 work is out! A collaboration with Matt Rasband’s lab in Nature Communications. This is a significant paper for the axon initial segment field. Matt’s lab used BioID of key AIS proteins for mapping AIS components. Dozens of new candidates for future studies!

Check all these new AIS proteins!

We performed super-resolution microscopy of several of the newly identified AIS components. IN particular, we showed that Mical3, a protein linking microtubules and actin, forms clusters along the AIS that are not periodically organized along the actin/spectrin scaffold.

Mical3 is present along the AIS but does not associate with the periodic actin/spectrin scaffold.